
What happens when artists from entirely different worlds step into the same studio? Sometimes they seem like a mismatch, yet time and again, these crossovers produced songs and performances that reshaped genres, won new audiences, and created unforgettable cultural moments. From Run-DMC and Aerosmith’s game-changing duet to Kanye West’s encounter with McCartney, these are the crossovers that shocked the world and left lasting echoes.
#1: Run-DMC and Aerosmith – “Walk This Way” (1986)
When hip-hop trailblazers Run-DMC joined forces with rock veterans Aerosmith, it looked strange on paper. Yet their reimagining of “Walk This Way” tore down barriers between genres, helped revive Aerosmith’s fading career, and gave hip-hop unprecedented exposure on MTV. The track rewrote music history by proving rap and rock could thrive together.

