#2: The Fall of Constantinople (1453)
When Ottoman cannons shattered Byzantine walls, the thousand-year empire of Rome’s east was gone overnight. Refugee scholars fled to Italy carrying priceless Greek manuscripts, jump-starting the Renaissance. Europe’s search for new trade routes redirected ships toward Africa and, ultimately, the Americas.

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One siege ended the Middle Ages, launched global exploration, and turned gunpowder into history’s new kingmaker.
